It's funny as monitor space increases, the mouse and keyboard cursor are more easily lost. My eyes aren't focusing where my cursors are, so sometimes I'll take actions that don't track with what the computer thinks I'm looking at. You minimise this app and look somewhere else, but meanwhile Windows has decided that some other app on the opposite side of your vast monitor array is where you're looking. Hit delete to try and remove an old email and accidentally wipe out a character in a document you were writing. It's a moment of discord, not badly out of place, but enough to make it feel like you and the computer aren't cooperating. Suddenly it's not an invisible window into the world of information. It's the dumb box in the corner that can't tell the difference between deleting spam and editing a report. And it matters primarily because a computer should be invisible and should never surprise you in a bad way.
Mokalus of Borg
PS - I only have this problem at work.
PPS - At home my monitor arrangements are more singular than plural.